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How many hours does trazodone last? by Drugs.com After a single dose in a healthy adult, trazodone will be mostly out of your system in one to three days. For trazodone the half-life is approximately 5 to 13 hours. This means that every 5 to 13 hours, the level in your blood will drop by 50 percent. What medicines can you not take with Trazodone? Drugs you should not use with trazodone Examples of these drugs include: Monoamine oxidase inhibitors (MOIs), such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You shouldn't take trazodone with MAOIs or within 14 days of taking them. Taking these drugs together raises your risk of serotonin syndrome. How much trazodone do I give my dog? The trazodone dosage for dogs ranges but a general guideline is around 2.5 mg per pound per day and up to 15 mg per pound given every 24 hours. On average the trazodone dosage for dogs is 3.5 mg per pound, per day, and lower doses are usually combined with other medications that aim to modify problematic behaviors.
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