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The safety population comprised 282 patients in the erlotinib group (259 in the 100 mg cohort and 23 in the 150 mg cohort) and 280 patients in the placebo group (256 in the 100 mg cohort and 24 in the 150 mg cohort).
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Of these, 174 patients with EGFR mutations were randomly assigned to receive erlotinib or platinum-based chemotherapy.
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This article reviews the use of gefitinib for the treatment of NSCLC from a pharmaceutical viewpoint.
Remarkably, both mutant receptors were more sensitive than the wild-type receptor to inhibition by gefitinib.
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Diese Ergebnisse führten dazu, dass die American Society of Clinical Oncology in ihren Leitlinien zur Behandlung nicht-kleinzelliger Bronchialkarzinome 2009 empfahl, bei Patienten mit EGFR-Mutationen Gefitinib einzusetzen.
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EGFR-expressing H1299 cells were maintained in regular culture condition (10% FCS) and the Tyre phosphorylations of EGFR proteins were examined by Western blotting using an anti-phosphotyrosine antibody 4G10.
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TUESDAY, Oct. 19, 2010 HealthDay News A small group of people with chronic myeloid leukemia CML who decided to stop taking the cancer drug Gleevec imatinib have remained cancerfree two years later, French researchers report.
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Although the relative risk of cancer does not decline to baseline levels for as long as 10 years after cessation, linked conditions (eg, chronic bronchitis, chronic obstructive pulmonary disease) show more rapid improvement or stabilization.
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Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients.
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