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Sixty-three percent of sickle cell subjects had neuropsychological dysfunction or abnormal findings on MRI, 38% had neuroimaging abnormalities, including silent infarcts and hippocampal atrophy, and 32% scored below 86 on the Wechsler Adult Intelligence Scale (WAIS) IQ scale.

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The original MSH study cohort included 299 men and women between 18 and 50 years old with a diagnosis of sickle cell anemia by gel electrophoresis conducted by a Core Laboratory.

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If both parents have the sickle cell trait, there is a 25 percent chance that their child will be born with sickle cell disease.

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Sickle cell disease (SCD) affects millions of people throughout the world and is particularly common among those whose ancestors came from sub-Saharan Africa; Spanish-speaking regions in the Western Hemisphere (South America, the Caribbean, and Central America); Saudi Arabia; India; and Mediterranean countries such as Turkey, Greece, and Italy.

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