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Sixty-three percent of sickle cell subjects had neuropsychological dysfunction or abnormal findings on MRI, 38% had neuroimaging abnormalities, including silent infarcts and hippocampal atrophy, and 32% scored below 86 on the Wechsler Adult Intelligence Scale (WAIS) IQ scale.
Acute chest syndrome can be fatal and must be treated immediately.
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The initial step following diagnosis of β-thalassemia in an individual is to distinguish between those who have thalassemia intermedia (requiring intermittent transfusions on an as-needed basis) from those with thalassemia major (who need a regular transfusion program).
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Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year.
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In practice, despite previously reported teratogenicity in animals with high doses, we did not find any major malformation among the 31 human pregnancies exposed to therapeutic doses of HU.
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The original MSH study cohort included 299 men and women between 18 and 50 years old with a diagnosis of sickle cell anemia by gel electrophoresis conducted by a Core Laboratory.
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These two terms acute and chronic are broad generalizations and it is necessary to treat them as such, the effects of leukemia may differ from one person to another and treatment will need to be tailored to individual needs and symptoms.
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If both parents have the sickle cell trait, there is a 25 percent chance that their child will be born with sickle cell disease.
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Sickle cell disease (SCD) affects millions of people throughout the world and is particularly common among those whose ancestors came from sub-Saharan Africa; Spanish-speaking regions in the Western Hemisphere (South America, the Caribbean, and Central America); Saudi Arabia; India; and Mediterranean countries such as Turkey, Greece, and Italy.
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Nevertheless, these complications might be related to the underlying haematological condition not to HU exposure.