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True, our medical school does have at least one credulous lecture about complementary and alternative medicine CAM that the medical students have to imbibe, but it really is pretty close to the bare minimum required by the accrediting agencies.

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Dose-normalized cyclosporine trough blood concentrations (TBC) were obtained before and after imatinib introduction.

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The molecular mechanism for primary imatinib resistance is unknown.

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The study was discontinued upon the advice of the Independent Data Monitoring Committee because a significant difference in relapse rate in favor of imatinib was observed (3% versus 17%).

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Growth retardation occurring in children and pre-adolescents receiving Imatinib Mesylate has been reported.

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The median time since diagnosis was 42 months, and median number of prior treatments was 3 (range, 1 to 5 treatments), including 11% with prior stem cell transplant.

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Continued approval for this indication may be contingent upon verification of clinical benefit in confirmatory trials.

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The median duration of exposure to peginterferon alfa-2a was 12 months (range, 1 week to 73 months) among all patients randomly assigned to receive imatinib and peginterferon alfa-2a and 8 months (range, 1 week to 46 months) among patients who discontinued the drug.

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