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I use methotrexate to treat my rheumatoid arthritis and I'm absolutely ok with the quality and effectiveness of the drug. I've been taking Methotrexate since 2009. My side effects are minimal. Once a week I may have nausea or slight migraine, but nothing more serious. My tests results have come back normal. Diclofenac helps with my rheumatoid arthritis a lot.



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One question i would ask: did the medicine get started by a rheumatologist or pediatric rheumatologist!

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Methotrexate is indicated in the management of selected adults with severe, active, rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis, who have had an insufficient therapeutic response to, or are intolerant of, an adequate trial of first-line therapy including full dose non-steroidal anti-inflammatory agents (NSAIDs).

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ULN occurred in 19% of 95 patients on methotrexate vs 3% of 94 on placebo; most common cause of drug withdrawal).

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Morgan SL, Baggott JE, Vaughn WH, Young PK, Austin JV, Krumdieck CL, and Alarcon GS ( 1990) The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.

This effect of methotrexate is attributed to its action of killing rapidly growing cells such as those of the placenta.

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